Complement-mediated hemolysis cannot be invoked to explain hemolytic disease of the newborn.
Answer the following questions by reading case study 1.It was stated that the Rh antigens are so sparsely scaered on the red cell surface that IgG molecules bound to the Rh antigens are too far apart to fix C1q. Therefore, complement-mediated hemolysis cannot be invoked to explain hemolytic disease of the newborn. By what mechanism are the red cells destroyed? 2 When an Rh-negative woman is ABO-compatible with her husband, as Mr and Mrs Waymarsh are, the risk of Rh alloimmunization is 16%. When they are ABO incompatible the risk falls to 7%. How do you explain this difference? 3 Why were Rh-negative red blood cells used for the intrauterine transfusion? 4 Do you have concerns about administering RhIG to women at 28 weeks of gestation? 5 The serum of an Rh-negative woman who is pregnant gives a negative indirect Coombs test but her serum agglutinates Rh-positive cells suspended in saline. What is your interpretation of this phenomenfjqon and what do you do about it?
Answer preview Complement-mediated hemolysis cannot be invoked to explain hemolytic disease of the newborn.
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