San Diego Based University Of California San Die

I encourage you to search internet and refer to additional literature to come up with possible answers. You may include scheme(s) and/or figure(s) to illustrate a particular point. Please follow the recommended word limits (including the figure captions). Also, note that your answers will be checked for plagiarism. (Full paper with figures is attached!) I will also attach some helpful powerpoints! This is a midterm so please cover every single thing asked in the question. Thank you!!

Question 1. San Diego–based Arena Pharmaceuticals’ anti-obesity drug – Lorcaserin (brand name – Belviq) was pulled from market in Jan 2020 due to concerns over cancer risks in patients. Explain the mode of action of Lorcaserin and its side-effects. This is one of the many anorexic drugs that have been pulled from market due to their adverse-effects (we looked at another example in the class called fen-phen). Summarize in a few sentences how getting a weight-loss treatment approved by the FDA is a little different compared to other drugs. (400 words max, 15 points)

Question 2. Isoprenaline (brand name – Isuprel) is a medication used for the treatment of bradycardia and heart block. Explain the mode of action of Isoprenaline and speculate why it might be more potent that the natural substrate that it mimics. (300 words max, 10 points)

Question 3. In the class, we studied Ames test to test the potential carcinogenicity of a compound. However, not all compounds that give positive Ames test are carcinogenic. For instance, cruciferous vegetables (e.g., broccoli, cabbage, mustard, etc.) will give a false-positive Ames test. Write a short summary of Ames test and discuss some of the mechanisms causing a false positive test, page 53 of the attached paper (400 words max, 10 points)

Question 4. Acetylcholinesterase hydrolyzes the neurotransmitter acetylcholine (Fig. 2). Using this as a guide, elaborate the mode of action of the compound shown in Fig. 3 (300 words max, 15 points)